The drama revolves around three twenty-somethings who, following an experimental gene therapy, are turned into monsters who band together to hunt down the scientist responsible and force him to make them human again. Dr. Sydney Burke, a brilliant scientist looking to fix her past mistakes, both professional and ethical, allies with Abbi, Juan and Tilda to track down the scientist responsible for their grim fates. Meanwhile, Dr. Alex Sarkov, a former child prodigy, refuses to let anyone or anything interfere with his goal of rewriting the human genome and ushering in the next stage of human evolution.