- Country: Japan
- Genres: Animation, Comedy, Drama
- Release: 2005-04-06
- Director: N/A
- Writers: N/A
- Language: Japanese
- Stars: Roger Craig Smith , Liam O’Brien , Sam Riegel , Patrick Seitz , Kirk Thornton , Kate Higgins (II) , Michelle Ruff , Wally Wingert , Neil Kaplan , Michael Sorich
- Runtime: 23 min
- Awards: N/A
- AKA: Eyeshield 21 (Canada) , Eyeshield 21 (United States of America) , Eyeshield 21 (Singapore) , 아이실드 21 (Korea) , Eyeshield 21 , Eye Shield 21: Le Yard de vaincre! (France, French Republic) , アイシールド21 (Japan) , 光速蒙面俠21 (Taiwan) , Eyeshield 21 (Indonesia) , Eyeshield 21 (Philippines)
- Plot: Kobayakawa Sena is a little guy who always get picked on by the bullies in school. Since elementary school, he always play the role of the 'errand boy' to the extent that he has become swift and fast in his movements. Coincidentally, Hiruma Youichi and Kurita Ryukan are looking for a fast running back for their American Football team (Amefuto) and want to put Sena in the team. To hide their new 'star' player from the eyes of other High Schools, Hiruma encases Sena in a Amefuto helmet with a dark visor and name him Eyeshield #21.
- IMDB:tt0996695
Eyeshield 21 Cast · · · ALL
Miyu Irino
Sena Kobayakawa / Eyeshield 21 (voice)
Atsushi Tamura
Yoichi Hiruma
Aya Hirano
Mamori Anezaki
Mamoru Miyano
Haruto Sakuraba
Kappei Yamaguchi
Raimon Tarou
Kouichi Nagano
Satoshi Muro
Daisuke Hirakawa
Hayato Akaba
Daisuke Ono
Kengo Mizumachi
Eiji Takemoto
Niinobu Kasamatsu
Hiroshi Shimozaki
Osamu Kobanzame
Kenji Hamada
Atsushi Munakata
Kenyu Horiuchi
Leonardo Apollo
Koji Yusa
Rui Habashira
Koji Ochiai
Hormer Fitzgerald
Masami Iwasaki
Koji Kuroki
Shoko Nakagawa
Suzuna
Kenji Nomura
Komusubi's Dad (voice)