- Country: Japan
- Genres: Action, Animation, Comedy
- Release: 2010-01-26
- Director: Suda 51
- Writers: Jared Hedges
- Language: English
- Stars: Robin Atkin Downes , Paula Tiso , Kimberly Brooks , Quinton Flynn , Matthew Mercer , Matthew Mercer , Khary Payton , Yuri Lowenthal , Yuri Lowenthal , Jennifer Hale (I) , Jennifer Hale (I) , Debi Derryberry , Debi Derryberry , Tara Strong , Tara Strong
- Runtime: min
- Awards: N/A
- AKA: Nô moa hîrôzu desuparêto sutoraguru (Japan) , No More Heroes 2: Desperate Struggle (United States of America) , No More Heroes 2: Desperate Struggle
- Plot: Travis returns to Santa Destroy only to find out that he's no longer officially the best assassin in the world, so he sets out to prove them all wrong while seeking revenge for his decapitated best friend.
- IMDB:tt1305728
No More Heroes: Desperate Struggle Cast
Suda 51
Director
Robin Atkin Downes
Travis Touchdown
Paula Tiso
Sylvia Christel
Kimberly Brooks
Shinobu Jacobs
Quinton Flynn
Henry
Matthew Mercer
Skelter Helter
Matthew Mercer
Bishop Shidux
Khary Payton
Nathan Copeland
Yuri Lowenthal
Charlie MacDonald
Yuri Lowenthal
Jasper Batt Jr.
Jennifer Hale
(I)
Kimmy Howell
Jennifer Hale
(I)
Alice Twilight
Debi Derryberry
Matt Helms
Debi Derryberry
Mimmy
Tara Strong
Cloe Walsh
Tara Strong
Margaret Moonlight